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Research

The Hayflick Limit Theory

There was some research done by a scientist named Leonard Hayflick on cell division. Leonard Hayflick found that when you put cells in a test tube and grow them, they divide only for a finite period of time before they stop dividing. This is known as the Hayflick limit, named after the scientist who discovered it.

Question: Is there a reason cell division stops?
Answer: Yes - latest evidence indicates there is a clock in each cell that is governed by a piece of DNA known as telomere. 

After each cell division, the telomere becomes a tiny bit shorter. When a critical amount of telomere has been removed, the cell can no longer divide. Its metabolism slows down, it ages, and dies.

There is hope! New evidence shows that the clock can be turned back on with the help of HGH.


Dr. Grace Wong Phd- HGH Hypothesis

Aging:

According to Dr. Wong, aging is due to the breakdown of proteins in the cell as well as the DNA and RNA that provide the blueprint for making protein. Skin, hair, bone, and muscle are all made of proteins, and as the proteins degrade, so do all of these things:

  • The skin wrinkles
  • Hair falls out
  • Muscles shrink
  • Bones lose density

Question: What causes these proteins to degrade?
Answer: The generation of oxygen free-radicals

Wong proposes that the oxygen radicals activate destructive enzymes called proteases that damage and degrade the proteins in the cell. When enough proteins have been damaged, the cell dies, followed by fragmentation of DNA. 

Growth hormone can activate a cellular defense force called protease inhibitors. These protease inhibitors prevent free radicals from doing any damage allowing the cells to stay healthy. This means your skin does not wrinkle, you do not lose energy, and your hair does not turn gray and fall out.


Adult Growth Hormone Therapy-Clinical Perspectives

Quality of Life Improves with GH Therapy

By Ron Rothenberg, MD
Ron Rothenberg, M.D. is Clinical Professor in Preventive and Family Medicine at the University of California, San Diego, School of Medicine. Dr. Rothenberg maintains a private practice at California Heathspan Institute in Encinatas, CA USA. Dr. Rothenberg may be contacted by telephone at (760) 635-1996, or by e-mail at info@eHealthSpan.com

In my anti-aging practice, I have about 160 patients being treated with growth hormone therapy (GHRT) for normal aging. One parameter which is often missing from evaluations of medical treatments is "quality of life" . Many factors come together to produce a good quality of life or more simply feeling good or feeling great. Just about every week a patient tells me something like, "This is the best I've felt in as long as I remember." Of course, I'm not just treating them with GHRT. Lifestyle comes first: nutrition, exercise, stress reduction. Beyond lifestyle, GHRT takes my patients to a different level of wellness and quality of life. There are consistent benefits mentioned by my patients.

My patients report improved memory and cognition, a more positive attitude and less depression. Discontinuing prescribed antidepressants is not uncommon. Many patients simply tell me that they feel happier. At times I have been told about an increased esthetic awareness of the beauty of the world. Body composition improves with more lean body mass and less fat mass. This is observed even when patients already had optimized diet and exercise programs before beginning GHRT. More rapid recovery from minor sports injuries is typical. Exercise performance increases. Patients report that they are told they look better, look healthier with better skin and often with reversal of hair loss. Combining GHRT and lifestyle in motivated patients often lead to objective lab values improving. Insulin sensitivity and cardiovascular risk factors including lipid profile and C-reactive protein are optimized. Other benefits mentioned in the medical literature such as reversal of atherosclerosis and improved immune function are difficult for patients to observe one way or the other.

Growth hormone is not a "fountain of youth" or a guarantee of immortality. Patients on GHRT are still prey to illnesses and injuries like anyone else. They are just operating on a younger, stronger, healthier physiological level.

One patient, a 52 year old attorney, explains it this way: When you are in your twenties, you don't get up in the morning and pound your chest and exclaim: I'm twenty and I feel great and I recovered quickly from that basketball game and I'm not gaining fat and sex is great! You just live your life and go with the ups and downs. After being on GHRT for a while that is what it is like. You don t marvel at the effects every day, you just live on a better level.

As anti-aging physicians, our goal is to rectangularize the functionality curve of the human lifespan, helping our patients to stay strong and vigorous as long as possible without gradual and protracted deterioration. We know GHRT is a proven defense against frailty and when added to lifestyle this is our chance to stay stronger and more functional. If we were to stay perfect, why intervene? But since we don't, this is one route to maintaining function while we await the genetic and biochemical therapies that will be available in the near future. Patients treated with GHRT are happier and healthier. Just ask one.

AAMN Editorial Note: There are several recent studies that document the positive effects of GH therapy in adults on quality of life measurements. These include:

NOVEMBER 2001 (KIGS/KIMS Outcomes Research, Pharmacia AB, Stockholm, Sweden): Data concerning visits to the doctor, number of days in hospital, and amount of sick leave were obtained from patients included in KIMS (Pharmacia International Metabolic Database), a large pharmacoepidemiological survey of hypopituitary adults with GH deficiency. Of the 304 patients surveyed, visits to the doctor, number of days in hospital, and amount of sick leave decreased significantly after 12 months of GH therapy. Patients also needed less assistance with daily activities, although this was significant only for the men. After 12 months of GH treatment, Quality of Life (assessed by the QoLAssessment of GHD in Adults questionnaire) improved, as did both the amount of physical activity and the patients' satisfaction with their level of physical activity. Dr. Hernberg and colleagues thus conclude that "GH replacement therapy, in previously untreated adults with growth hormone deficiency, produces significant decreases in the use of healthcare resources, which are correlated with improvements in quality of life."

SEPTEMBER 2001 (Universitat Munchen, Munich, Germany): Dr. Herschbach and colleagues from the Institut und Poliklinik fur Psychosomatische Medizin found scores across numerous psychometric markers improved progressively in adults administered GH replacement therapy.

JUNE 2001 (Royal Liverpool University Hospital, United Kingdom): Dr. Ahmad and team found that weight-based GH replacement resulted in significant improvements in both body composition and quality of life as early as one month after the initiation of treatment, and persisted at three months. Noting that "most importantly, these changes occur in the absence of side-effects," the researchers "therefore suggest the use of low-dose GH therapy, maintaining IGF-I between the median and upper end of the age-related reference range, for the treatment of adult growth hormone deficiency."

During normal aging, men and women experience a decrease of growth hormone secretion of up to 60%. As our abstracts review and Dr. Rothenberg's insights suggest, determination of an individual s suitability for GH replacement therapy must be based on a complete clinical evaluation that identifies declining physical, cognitive, or psychological parameters - either or both of which may cause a decrease in the individual's quality of life. As Dr. Delgado points out, a regimen of low-dose GH treatment coupled with supporting hormones and nutrients can achieve impressive age-reversal results.

Admittingly, the discussion over the long-term efficacy of GH replacement will undoubtedly continue. As an evolving science, it is likely that vacillations of study findings will continue for quite some time, and they reinforce the fact that GH therapy in adults for any reason - including specific disease treatment as well anti-aging purposes - must be conducted judiciously by a physician trained in this treatment.

In closing, we cite one of the newest studies reaffirming the safety of prudent GH therapy. In May 2002, Dr. Kehely and colleagues in the United Kingdom published findings on their two-tier parallel study. In one group of GH deficient adults, they administered a low dose regimen (3 mcg/kg/day for 3 months, increasing to 6 mcg/kg/day for 3 more months) versus conventional dose (6 mcg/kg/day, increasing to 12 mcg/kg/day for 3 more months). The proportion of patients completing low-dose therapy was greater than for the conventional dose group. While both dose groups showed significant increases in lean body mass and decreases in fat mass for all time points, subjects in the low-dose group were better able to maintain the gain in lean body mass for the six-month study period. There also were fewer reports of adverse events (arthralgia) with the low-dose therapy. The lower starting dose with dose titration appeared more favorable, but researchers note that individual variability also requires consideration.

When supervised by a qualified anti-aging physician, evidence to-date indicates that GH replacement therapy is valuable in maintaining both physical fitness and mental acuity in adult men and women.

RESOURCES

Delgado N. Grow Young and Slim 2nd Edn: #1 Way to Fitness. HWS (Las Vegas Nevada), in-publication (anticipated publication date 2003).
Grow Young and Slim, at www.growyoungandslim.com

REFERENCES

Ahmad AM, Hopkins MT, Thomas J, Ibrahim H, Fraser WD, Vora JP. Body composition and quality of life in adults with growth hormone deficiency; effects of low-dose growth hormone replacement. Clin Endocrinol (Oxf). 2001 Jun;54(6):709-17.
Attanasio AF, Bates PC, Ho KK, Webb SM, Ross RJ, Strasburger CJ, Bouillon R, Crowe B, Selander K, Valle D, Lamberts SW; The Hypoptiuitary Control and Complications Study International Advisory Board. Human growth hormone replacement in adult hypopituitary patients: long-term effects on body composition and lipid status-3-year results from the HypoCCS Database. J Clin Endocrinol Metab. 2002 Apr;87(4):1600-6.
Clanget C, Seck T, Hinke V, Wuster C, Ziegler R, Pfeilschifter J. Effects of 6 years of growth hormone (GH) treatment on bone mineral density in GH-deficient adults. Clin Endocrinol (Oxf). 2001 Jul;55(1):93-9.
Ezzat S, Fear S, Gaillard RC, Gayle C, Landy H, Marcovitz S, Mattioni T, Nussey S, Rees A, Svanberg E. Gender-specific responses of lean body composition and nongender- specific cardiac function improvement after GH replacement in GHdeficient adults. J Clin Endocrinol Metab. 2002 Jun;87(6):2725-33.
Gillberg P, Bramnert M, Thoren M, Werner S, Johannsson G, Commencing growth hormone replacement in adults with a fixed low dose. Effects on serum lipoproteins, glucose metabolism, body composition, and cardiovascular function, Growth Horm IGF Res. 2001 Oct;11(5):273-81.
Gotherstrom G, vensson J, Koranyi J, Alpsten M, Bosaeus I, Bengtsson B, Johannsson G, A prospective study of 5 years of GH replacement therapy in GH-deficient adults: sustained effects on body composition, bone mass, and metabolic indices, J Clin Endocrinol Metab. 2001 Oct;86(10):4657-65.
Hernberg-Stahl E, Luger A, Abs R, Bengtsson BA, Feldt-Rasmussen U, Wilton P, Westberg B, Monson JP; KIMS International Board., KIMS Study Group.
Pharmacia International Metabolic Database, Healthcare consumption decreases in parallel with improvements in quality of life during GH replacement in hypopituitary adults with GH deficiency, J Clin Endocrinol Metab. 2001 Nov;86(11):5277-81
Herschbach P, Henrich G, Strasburger CJ, Feldmeier H, Marin F, Attanasio AM, Blum WF. Development and psychometric properties of a disease-specific quality of life questionnaire for adult patients with growth hormone deficiency. Eur J Endocrinol. 2001 Sep;145(3):255-65.
Kehely A, Bates PC, Frewer P, Birkett M, Blum WF, Mamessier P, Ezzat S, Ho KK, Lombardi G, Luger A, Marek J, Russell-Jones D, Sonksen P, Attanasio AF. Shortterm safety and efficacy of human GH replacement therapy in 595 adults with GH deficiency: a comparison of two dosage algorithms. J Clin Endocrinol Metab. 2002 May;87(5):1974-9.
Murray RD, Wieringa GE, Lissett CA, Darzy KH, Smethurst LE, Shalet SM. Low-dose GH replacement improves the adverse lipid profile associated with the adult GH deficiency syndrome. Clin Endocrinol (Oxf). 2002 Apr;56(4):525-32.
Napoli R, Guardasole V, Matarazzo M, Palmieri EA, Oliviero U, Fazio S, Sacca L. Growth hormone corrects vascular dysfunction in patients with chronic heart failure. J Am Coll Cardiol. 2002 Jan 2;39(1):90-5. Napolitano LA, Lo JC, Gotway MB, Mulligan K, Barbour JD, Schmidt D, Grant RM, Halvorsen RA, Schambelan M, McCune JM. Increased thymic mass and circulating naive CD4 T cells in HIV-1-infected adults treated with growth hormone. AIDS. 2002 May 24;16(8):1103-11.
Rudman D, Feller AG, Nagraj HS, Gergans GA, Lalitha PY, Goldenberg AF, Schlenker RA, Cohn L, Rudman IW, Mattson DE. Effects of human growth hormone in men over 60 years old, N Engl J Med1990 Jul 5:323(1):1-6.
Smith JC, Lang D, McEneny J, Evans LM, Scanlon MF, Young I, Davies J. Effects of GH on lipid peroxidation and neutrophil superoxide anion-generating capacity in hypopituitary adults with GH deficiency. Clin Endocrinol (Oxf). 2002 Apr;56(4):449-55.
Sohmiya M, Kato Y. Effect of long-term administration of recombinant human growth hormone (rhGH) on plasma erythropoietin (EPO) and haemoglobin levels in anaemic patients with adult GH deficiency. Clin Endocrinol (Oxf). 2001 Dec;55(6):749-54.
Ueland T, Bollerslev J, Flyvbjerg A, Hansen TB, Vahl N, Mosekilde L. Effects of 12 months of GH treatment on cortical and trabecular bone content of IGFs and OPG in adults with acquired GH deficiency: a double-blind, randomized, placebocontrolled study. J Clin Endocrinol Metab. 2002 Jun;87(6):2760-3.
Wallace JD, Abbott-Johnson WJ, Crawford DH, Barnard R, Potter JM, Cuneo RC. GH treatment in adults with chronic liver disease: a randomized, double-blind, placebocontrolled, cross-over study. J Clin Endocrinol Metab. 2002 Jun;87(6):2751-9.

An original article as appeared in Anti-Aging Medical News, Summer-Fall 2002, published by the A4M.


Question: Can growth hormone safely and effectively help me do the miraculous things described above.
Answer: Almost. Researchers and pharmaceutical companies are on the search for an HGH pill that does not have the side effects of injections, but can produce the same results.

 

Recommendation: Doctors and scientists are now recommending natural HGH stimulants until there is a pill available that is free from side effects.

To learn more about natural HGH stimulants, click here for a natural supplement called rejuvence.

 

 

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